| Giocatore | Trasferimento | Contratto | Data |
| Randy Nteka |
CF Fuenlabrada Rayo Vallecano |
? | 28-07-2021 |
| Pathé Ciss |
CF Fuenlabrada Rayo Vallecano |
? | 28-07-2021 |
| Sergi Gómez |
Siviglia FC Espanyol |
5,00 mln € | 28-07-2021 |
| Martín Calderón |
RM Castiglia Cádice CF |
gratuito | 27-07-2021 |
| Dani Calvo |
Elche CF Real Oviedo |
gratuito | 27-07-2021 |
| Bryan Gil |
Siviglia FC Tottenham |
- | 26-07-2021 |
| Erik Lamela |
Tottenham Siviglia FC |
gratuito | 26-07-2021 |
| Diego Rico |
Bournemouth Real Sociedad |
12,00 mln € | 26-07-2021 |
| Paulo Gazzaniga |
Tottenham FC Fulham |
Fine prestito | 24-07-2021 |
| Mamadou Loum |
FC Porto Alavés |
Prestito | 23-07-2021 |
| Cheick Doukouré |
Levante UD CD Leganés |
1,60 mln € | 23-07-2021 |
| Juan Berrocal |
Siviglia FC Sporting Gijón |
Prestito | 22-07-2021 |
| Florian Lejeune |
Newcastle Utd. Alavés |
Prestito | 22-07-2021 |
| Paulinho |
GuaZ FC Ahli |
40,00 mln € | 22-07-2021 |
| Sergio Carreira |
Celta de Vigo CD Mirandés |
Prestito | 20-07-2021 |
| Miguel Cifuentes |
Elche CF UD Ibiza |
Prestito | 20-07-2021 |
| Martín Pascual |
Rayo Vallecano Villarreal CF B |
Prestito | 19-07-2021 |
| Brahim Díaz |
Real Madrid Milan |
17,30 mln € | 19-07-2021 |
| Gabriel Fernández |
Celta de Vigo FC Juárez |
Prestito | 19-07-2021 |
| Kévin Gameiro |
Valencia CF Strasburgo |
? | 18-07-2021 |
| Ramón Folch |
Elche CF CE Sabadell |
gratuito | 17-07-2021 |
| Brandon Thomas |
CA Osasuna Málaga CF |
gratuito | 16-07-2021 |
| Ibai Gómez |
Athletic svincolato |
4,00 mln € | 16-07-2021 |
| Monchu |
Barcellona Granada CF |
- | 16-07-2021 |
| Fran Gámez |
RCD Mallorca Real Saragozza |
gratuito | 15-07-2021 |
| José Matos |
Cádice CF svincolato |
- | 15-07-2021 |
| Xabi Etxeita |
Getafe CF SD Eibar |
gratuito | 15-07-2021 |
| Iván Balliu |
UD Almería Rayo Vallecano |
gratuito | 14-07-2021 |
| Boulaye Dia |
Stade Reims Villarreal CF |
12,00 mln € | 13-07-2021 |
| Lionel Carole |
Strasburgo Kayserispor |
Spesa prestito:350 mila € | 13-07-2021 |